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Comprehensive Metabolic Panel (CMP): What It Tests and Why It Matters

Written by Bonnie Green on June 20, 2025

Cmp testMetabolic panelBlood testLiver functionKidney function
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If you’re trying to get a clearer picture of your overall health — especially when it comes to your liver, kidneys, blood sugar, and electrolytes — the Comprehensive Metabolic Panel (CMP) is one of the best tools available. It’s widely used in both routine checkups and diagnostics, giving clinicians vital information about how your body’s internal systems are working.

At RateMyLab.com, the CMP is one of the most searched tests, often because it’s included in preventive screening bundles. In this article, we’ll break down what the CMP tests for, when you should get one, and what your results may mean.


What Is a CMP?

A Comprehensive Metabolic Panel is a group of 14 blood tests that analyze the chemical balance and metabolism of your body. It’s typically ordered to evaluate organ function, especially your liver and kidneys, and to check for conditions like diabetes, dehydration, or electrolyte imbalances.

It includes:

  • Glucose – your blood sugar level
  • Calcium – vital for bone, nerve, and muscle function
  • Albumin – a liver-made protein important for nutrient transport
  • Total Protein – includes albumin and globulin
  • Sodium, Potassium, Chloride, CO₂ (Bicarbonate) – electrolytes that maintain fluid and pH balance
  • Blood Urea Nitrogen (BUN) and Creatinine – indicators of kidney function
  • Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Aspartate Transaminase (AST), and Bilirubin – liver enzymes that reflect liver health or damage

Why Is It Ordered?

The CMP can reveal early signs of:

  • Diabetes or blood sugar dysregulation
  • Liver disease (e.g., fatty liver, hepatitis, cirrhosis)
  • Kidney dysfunction or failure
  • Electrolyte imbalance due to dehydration, medications, or chronic illness
  • Side effects of medications affecting the liver or kidneys

Doctors often order it as part of:

  • Annual wellness exams
  • Pre-surgical screening
  • Chronic disease monitoring
  • Emergency evaluations for symptoms like fatigue, confusion, nausea, or swelling

How Do You Prepare for a CMP?

Unlike many other tests, a CMP usually requires fasting for 8–12 hours before your blood draw, especially to get accurate glucose and calcium levels. Always check with your healthcare provider or the lab for instructions.


What Do the Results Mean?

CMP results help identify specific dysfunctions:

  • High glucose → could indicate prediabetes or diabetes
  • Abnormal liver enzymes (ALT, AST, ALP, Bilirubin) → suggest liver inflammation, bile duct issues, or even medication toxicity
  • Low albumin or total protein → may reflect poor nutrition, liver disease, or kidney problems
  • Elevated BUN or creatinine → potential kidney impairment
  • Electrolyte imbalances → may signal dehydration, kidney issues, or hormonal disorders

No single result is a diagnosis on its own — but patterns in the data can be very revealing.


Cost Differences You Should Know

What many patients don’t realize is that the same CMP test can range in cost from $15 to $70, depending on where and how you order it. At RateMyLab.com, we help users compare real-time prices for CMPs from trusted providers and lab networks — often saving 40–60% compared to walk-in rates.


Who Should Get a CMP?

A CMP may be recommended if you:

  • Are experiencing symptoms like fatigue, swelling, nausea, or confusion
  • Are managing conditions like diabetes, high blood pressure, or kidney disease
  • Are taking medications that can affect liver or kidney function
  • Want a baseline to track your long-term wellness

Even if you’re feeling well, the CMP can be a valuable early-warning system for problems that haven’t shown symptoms yet.


Final Thoughts

The Comprehensive Metabolic Panel is one of the best value lab tests available — it packs a ton of important information into a single blood draw. And when you can compare prices from multiple providers with RateMyLab.com, it becomes even more accessible.

Whether you’re tracking your health proactively or trying to figure out what’s behind troubling symptoms, a CMP is an essential step.

👉 Check current CMP test prices now at RateMyLab.com and take smarter control of your health.